What is the maximum mean airway pressure value that should not be exceeded in a six-week-old neonate ventilated with pressure control?

In the context of mechanical ventilation for a six-week-old neonate, it is essential to consider the safety and potential adverse effects of high airway pressures. The maximum mean airway pressure (MAWP) that should not be exceeded is critical for preventing lung injury and ensuring adequate gas exchange without compromising the delicate pulmonary physiology of neonates.

A mean airway pressure of around 15 cmH2O is generally regarded as the upper limit in this age group when using pressure control ventilation. This allows for sufficient recruitment of collapsed alveoli while minimizing the risk of barotrauma or volutrauma, which are significant concerns in neonatal populations due to the immature lung tissue.

Moreover, this value has been derived from clinical practice guidelines and empirical studies, indicating that exceeding this level can increase the risk of adverse outcomes such as lung injury and negatively impact hemodynamics due to increased intrathoracic pressures.

In summary, maintaining the mean airway pressure at or below 15 cmH2O balances the need for effective ventilation while protecting the neonate’s lungs from injury.